GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer

GPR54 is a target for suppression of metastasis in endometrial cancer.

Invasion into deep myometrium and/or lymphovascular space is a well-known risk factor for endometrial cancer metastasis, resulting in poor prognosis. It is therefore clinically important to identify novel molecules that suppress tumor invasion. Reduced expression of the metastasis suppressor, kisspeptin (KISS1), and its endogenous receptor, GPR54, has been reported in several cancers, but the s...

Ovarian Metastasis in Endometriod Type Endometrial Cancer

ovarian metastasis in endometriod type endometrial cancer

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USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment

Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. Most endometrial cancer cases are diagnosed at an early stage and have good prognosis. Unfortunately a subset of patients with early stage and low grade disease experience recurrence for reasons that remain unclear. Recurrence is often accompanied by chemoresistance and high mortality.Deubiquitinating enz...

Adrenal Gland Metastasis Is an Unusual Manifestation of Endometrial Cancer

This case report describes a woman treated for stage 1 B grade 3 endometrial adenocarcinoma with surgery and adjuvant radiation therapy who presented 6 months later with pain and symptoms of adrenal insufficiency. A large right adrenal mass revealed adenocarcinoma consistent with the endometrial primary.